Sonicator Baths for Sample Prep

How to Use a Sonicator Bath for Sample Prep in Pharmaceutical Research

Sample preparation is defined by the International Union of Pure and Applied Chemistry (IUPAC) as the process used to transform analytes into a measurable form.  Several terms are used to describe the equipment used for sample prep, among which are sonicator baths.

For example, in Sample Preparation of Pharmaceutical Dosage Forms, “sonicators, also referred to as ultrasonic extraction, can be considered both particle size reduction techniques and an agitation technique.  Because of its ability to disperse, mix and dissolve samples, it is widely used in the sample preparation of dosage forms.”

Sonicator baths, sonicators and ultrasonic cleaners are terms describing equipment commonly employed in drug design and development. Because the term “ultrasonic cleaner” is a bit misleading in this context (normally associated with thorough cleaning of parts) we’ll use sonicator bath in this post.

The Purpose of Sonicators

Sonication is one of the processes used in sample preparation to … Read the rest

How to Select an Explosion Proof Ultrasonic Cleaner

How to Select an Explosion Proof Ultrasonic Cleaner

Ultrasonic cleaning with volatile (flammable) solvents creates what the NEC and NFPA term a hazardous location.  Conformance requires that you follow strict procedures including selecting an explosion proof ultrasonic cleaner or taking special precautions when using low flash point volatile solvents for cleaning. This post describes volatile solvents, where they are used in ultrasonic cleaning operations and how to comply with regulations including explosion-proof ultrasonic cleaners. 

What is a Flash Point?

A flash point is the temperature at which a particular organic compound gives off sufficient vapor to ignite in air when given an ignition source.  Gasoline fumes are an example.  Although you can extinguish a match by dunking it in gasoline, such an exercise is not recommended because it is the gasoline fumes that ignite.  

In view of this, selection of an ultrasonic cleaner must take into account that not only do volatile solvents evaporate, but the heat … Read the rest

Dental Instrument Ultrasonic Cleaning

How to Select Dental Ultrasonic Cleaners

Ultrasonic cleaning is among recommendations in the CDC’s Summary of Infection Prevention Practices in Dental Settings to remove contaminants from reusable dental instruments.   Cleaning before sterilization avoids heat “baking on” blood, tissue and other organic residues that cause infection problems.  As described in this post dental instrument ultrasonic cleaning systems are also ideal for cleaning molds, implant hybrid prosthesis, and removing plaster and cement from bridgework.  

Why You Need an Ultrasonic Dental Instrument Cleaner

Ultrasonic energy creates billions of minute vacuum bubbles in an ultrasonic cleaning bath that implode with tremendous force when they contact dental instruments. 

The process, called cavitation, reaches into tiny cracks and crevices, quickly and safely blasting loose and carrying away contaminants on dental instrument surfaces.  It is a much faster … Read the rest

How to Use an Ultrasonic Bath to Make Liposomal Vitamin C

Header DIY Liposomal Vitamin C
Do It Yourself Liposoal C Maker Kit
An ultrasonic cleaner for making liposomal encapsulated vitamin C

Liposomal encapsulated vitamin C offers a high absorption efficiency vs. taking vitamin C pills and is much more convenient than intravenous administration.   Due to the Coronavirus pandemic there has been an increase in demand for vitamin C as a means of protection or treatment while a recent report states that demand for liposomal vitamin C has outpaced that for hand sanitizers*.  Because liposomal vitamin C has a short shelf life, this post tells you how to make it yourself using an ultrasonic bath and a beaker kit.  

Why Ultrasonic Energy Delivers Superior Liposomal Vitamin C

While it uses a benchtop ultrasonic cleaner, the process employs the power of what is called ultrasonic cavitation to encapsulate ascorbic acid within liposomes.  Encapsulation improves the bioavailability of the vitamin C in your body.

Ultrasonic processing is also preferred as a means of reducing … Read the rest

How Ultrasonic Cleaners Protect Dentists in the Corona Virus Pandemic

How Ultrasonic Cleaners Protect Dentists in the Corona Virus Pandemic

The American Dental Association releases guideline updates on how dental technicians can protect themselves during the current Corona Virus pandemic.  The ADA on March 16 encouraged dental practitioners to postpone elective procedures for the next three weeks.  It also refers dentists to conform to CDC guidelines for sterilizing and disinfecting patient care items and devices.

These guidelines refer to reusable dental instruments, and among other techniques recommend the use of ultrasonic cleaners as a pre-sterilization or disinfecting procedure to render them safely for reuse.

Ultrasonic Cleaners In CDC Recommendations for Covid-19 Infection Control

The CDC’s 2008 Infection and Sterilization Guideline notes that “The most common types of mechanical or automatic cleaners are ultrasonic cleaners…” and that “Ultrasonic cleaning removes soil by cavitation and implosion in which waves of acoustic energy are propagated in aqueous solutions to disrupt the bonds that hold particulate matter to surfaces.”

Note that ultrasonic cleaning … Read the rest

When Do You Need a Heated Ultrasonic Cleaner?

What is a Heated Ultrasonic Cleaner?

A heated ultrasonic cleaner is recommended for tough cleaning jobs generally involving deposits of heavy grease, grime, residues in plastic injection molds, tough carbon deposits on engine parts and similarly difficult cleaning challenges.  Just as hot water is better for cleaning greasy dishes, pots and pans, a heated ultrasonic cleaning solution often “works best” solving tough cleaning challenges.

When Not to Use a Heated Ultrasonic Cleaner

There are certain applications where heat is not necessarily desirable when using an ultrasonic cleaner.

An example is the use of an ultrasonic cleaner as a pre-sterilization or disinfecting step for medical and surgical instruments.

Blood and tissue should be removed from instruments at a temperature below 40⁰C (104⁰F).  That’s because elevating the temperature can cause protein in blood to harden and become more difficult to clean. For more details on this see our post on cleaning surgical instruments.

Heat may also cause … Read the rest

How Ultrasonic Cleaning Brass Can Restore Gleam

Restore the Gleam of Brass with an Ultrasonic Cleaner

Those appreciating the gleam of brass – whether fireplace andirons & tools, chandeliers, escutcheons, or antique decorative brass hardware of any description – also appreciate the work that goes into restoring and maintaining the gleam of brass.  Chemical-based brass cleaners on the market usually require lots of time to apply and buff it off to reveal the shine.  This post describes how ultrasonic cleaning brass can help savvy collectors or sellers of brass products restore the gleam of antique brass. 

Why Ultrasonic Cleaning Brass Works so Well

The power of ultrasonic cavitation in an ultrasonic cleaner removes heat marks, soot deposits and other grime on fireplace implements that accumulates over the heating season. 

Similarly it removes tarnish and other surface deposits on brass door knockers, mail slots, latches, name plates, switch plates – in fact any decorative or functional product made of brass.

As suggested above, sonic cleaning also avoids … Read the rest

Brass Musical Instruments: Restored with Ultrasonic Cleaners

How to Clean Brass Instruments with Ultrasonic Cleaners

Brass musical instrument owners whether individuals, professional organizations such as orchestras, school, university or performance bands, want to keep the brass sparkling and shining. Maintaining brass musical instrument sparkle and shine is fast and easy with an ultrasonic cleaner and a regular music instrument cleaning program.  This post describe how ultrasonic energy speeds brass cleaning to restore and maintain sparkle and shine. 

Ultrasonic Brass Instrument Cleaning where Hands Can’t Reach

Anyone who experienced the time consuming task of restoring the shine to their brass musical instruments will take pleasure in the efficacy of ultrasonic cleaning vs. brushes, calcium remover,  vinegar, water and other techniques found when Googling the topic.

The efficacy of an ultrasonic cleaner is due to the fact that cleaning action – called cavitation – reaches every area wetted when brass instruments are immersed in an ultrasonic cleaning solution that is temperature controlled so that it will not … Read the rest

How to Safely Clean and Restore Classic Vinyl Records with the CleanerVinyl Pro

Safely Clean and Restore Classic Vinyl Records with CleanerVinyl Pro

A large and growing number of audiophiles have turned their backs on compact disc recordings and other digital sources in favor of vinyl LP and 45 RPM recordings either released now as new audiophile pressings or as vintage records from more than nine decades of recording history.

CleanerVinyl Pro with records
CleanVinyl Pro record cleaning system installed on an Elma P60H dual-frequency ultrasonic cleaner.

Be it the removal of release agents and other chemicals from the pressing process, or bringing vintage vinyl back to life after years of storage, this is a task eased considerably by the CleanerVinyl Pro ultrasonic record cleaning system. 

This post describes why ultrasonic record cleaning is so effective, and how the CleanerVinyl Pro System incorporating an Elmasonic P60H dual-frequency ultrasonic cleaner does the job.

Why Ultrasonic Cleaning is Best for Restoring Vinyl Records

There are many methods for record cleaning. Most are based of some kind of brushing, washing … Read the rest

How to Degas Liquids with Ultrasonic Energy

How to Degas Liquids with Ultrasonic Energy

Degassing liquids of various viscosities is undertaken across a broad spectrum of industries and for a variety of reasons. Before describing how ultrasonic energy achieves fast, efficient degassing we provide you with a few definitions.

Degassing Defined

Degassing, as the name suggests, is removing trapped air (deaeration) or other gases from liquids.  Most if not all liquids contain trapped air.  You can see that by allowing a glass of water to remain on the countertop for a period of time.  Bubbles will form on the walls of the glass. 

A more vivid demonstration is opening a bottle of seltzer, carbonated beverage, champagne or beer.  Bubbles fizz immediately after the pressure in the container is reduced.  In this case the gas being removed is carbon dioxide rather than air.

But degassing is also necessary to remove trapped air from oils, adhesives and paint among other products where the air can interfere … Read the rest