Guide to CDC Recommended Laboratory and Medical Refrigerators and Freezers for Vaccine Storage

Vaccine Storage

CDC Recommendations for Approved Laboratory, Medical, and Biomedical Refrigerators and Freezers for Vaccine Storage

Maintaining a cold chain through-out the entire vaccine supply chain is critical to the safety and security of vaccines. According to the CDC, the cold chain begins with the cold storage unit at the manufacturing plant, extends to the transport and delivery of the vaccine and proper storage at the provider facility, and ends with the  administration of the vaccine to the patient.

Additionally, the CDC stresses in its Vaccine Storage and Handling Pink Book that manufacturers, distributors, public health staff, and health care providers share responsibility to ensure the vaccine cold chain is maintained from the time vaccines are manufactured until they are administered.

To ensure safe vaccine storage, medical grade laboratory, pharmacy, and biomedical refrigerators and freezers must comply with … Read the rest

How to Pick the Best Ultrasonic Cleaner: 10 Tips

How to Pick the Best Ultrasonic Cleaner:

Selecting the best
ultrasonic cleaner for your job should involve the same careful thought
processes you'd go through when making other important purchasing decisions -
such as an automobile or computer.  What
features are important to you?  Balancing
"needs" with "nice to have" applies to any significant
purchase. 

When you arm yourself with these 10 tips you are on the way to select the ultrasonic cleaner to do the jobs you need to do at the best price. The 10 tips are as follows:

No time to review the complete article? No problem.

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Sonicator Baths for Sample Prep

How to Use a Sonicator Bath for Sample Prep in Pharmaceutical Research

Sample preparation is defined by the International Union of Pure and Applied Chemistry (IUPAC) as the process used to transform analytes into a measurable form.  Several terms are used to describe the equipment used for sample prep, among which are sonicator baths.

For example, in Sample Preparation of Pharmaceutical Dosage Forms, “sonicators, also referred to as ultrasonic extraction, can be considered both particle size reduction techniques and an agitation technique.  Because of its ability to disperse, mix and dissolve samples, it is widely used in the sample preparation of dosage forms.”

Sonicator baths, sonicators and ultrasonic cleaners are terms describing equipment commonly employed in drug design and development. Because the term “ultrasonic cleaner” is a bit misleading in this context (normally associated with thorough cleaning of parts) we’ll use sonicator bath in this post.

The Purpose of Sonicators

Sonication is one of the processes used in sample preparation to … Read the rest

How to Calibrate a Digital Scale

How to Calibrate a Scale

When it comes to explaining how to calibrate a digital scale, here’s a bit of reassurance:  Calibrating a digital scale is not that complicated.  While scale calibration is important, here you will learn why and how often digital scales should be calibrated.

We’re talking not only precision scales and analytical balances able to weigh in grams and milligrams but also industrial scales weighing in pounds, sales used for recipes, determining percentages, totalizing, counting and other functions used in industry today.

Why you Should Know How to Calibrate a Digital Scale

First of all, in many instances it’s required by law.  For example, calibration standards used for inspection, measuring, and test equipment shall be traceable to national or international standards.

One of these is the National Institute of Standards and Technology’s Weights and Measures Program Requirements, which provides detailed information on this topic.

The FDA document observes that if national … Read the rest

Moisture Analysis: What is Moisture Analyzer?

What is a Moisture Analyzer?

Let’s start out by explaining why you may need a moisture analyzer.  One example (of many) is in the food industry.  As described in Food Quality and Safety  “International and national standards define the permitted thresholds for moisture content in commercially sold products.” 

After listing some of these standards, the article continues “….this translates into increased workload around quality assurance and the development of efficient and cost-effective solutions. According to the stated legal requirements, methods of analysis and procedures must be clearly described and tested.”

Moisture analyzers are widely used in meeting these standards.  They go far beyond the food industry – affecting such diverse products as pharmaceuticals, plastics, paint, wood, birdseed, soybeans, fertilizer, cement, detergent, shampoo…..etc.

So, What is Moisture?

Excellent Question.  For the subject of this post, moisture is anything that evaporates on heating.

In addition to water this may include fats, oils alcohol and solvents.

Please note … Read the rest

How to Select an Explosion Proof Ultrasonic Cleaner

How to Select an Explosion Proof Ultrasonic Cleaner

Ultrasonic cleaning with volatile (flammable) solvents creates what the NEC and NFPA term a hazardous location.  Conformance requires that you follow strict procedures including selecting an explosion proof ultrasonic cleaner or taking special precautions when using low flash point volatile solvents for cleaning. This post describes volatile solvents, where they are used in ultrasonic cleaning operations and how to comply with regulations including explosion-proof ultrasonic cleaners. 

What is a Flash Point?

A flash point is the temperature at which a particular organic compound gives off sufficient vapor to ignite in air when given an ignition source.  Gasoline fumes are an example.  Although you can extinguish a match by dunking it in gasoline, such an exercise is not recommended because it is the gasoline fumes that ignite.  

In view of this, selection of an ultrasonic cleaner must take into account that not only do volatile solvents evaporate, but the heat … Read the rest

Dental Instrument Ultrasonic Cleaning

How to Select Dental Ultrasonic Cleaners

Ultrasonic cleaning is among recommendations in the CDC’s Summary of Infection Prevention Practices in Dental Settings to remove contaminants from reusable dental instruments.   Cleaning before sterilization avoids heat “baking on” blood, tissue and other organic residues that cause infection problems.  As described in this post dental instrument ultrasonic cleaning systems are also ideal for cleaning molds, implant hybrid prosthesis, and removing plaster and cement from bridgework.  

Why You Need an Ultrasonic Dental Instrument Cleaner

Ultrasonic energy creates billions of minute vacuum bubbles in an ultrasonic cleaning bath that implode with tremendous force when they contact dental instruments. 

The process, called cavitation, reaches into tiny cracks and crevices, quickly and safely blasting loose and carrying away contaminants on dental instrument surfaces.  It is a much faster … Read the rest

How to Use an Ultrasonic Bath to Make Liposomal Vitamin C

Header DIY Liposomal Vitamin C
Do It Yourself Liposoal C Maker Kit
An ultrasonic cleaner for making liposomal encapsulated vitamin C

Liposomal encapsulated vitamin C offers a high absorption efficiency vs. taking vitamin C pills and is much more convenient than intravenous administration.   Due to the Coronavirus pandemic there has been an increase in demand for vitamin C as a means of protection or treatment while a recent report states that demand for liposomal vitamin C has outpaced that for hand sanitizers*.  Because liposomal vitamin C has a short shelf life, this post tells you how to make it yourself using an ultrasonic bath and a beaker kit.  

Why Ultrasonic Energy Delivers Superior Liposomal Vitamin C

While it uses a benchtop ultrasonic cleaner, the process employs the power of what is called ultrasonic cavitation to encapsulate ascorbic acid within liposomes.  Encapsulation improves the bioavailability of the vitamin C in your body.

Ultrasonic processing is also preferred as a means of reducing … Read the rest

CDC Refrigeration Guidelines for Submitting COVID-19 Specimens for Testing

Plan for COVID-19 Vaccine Storage

While the search for a Coronavirus vaccine proceeds at full throttle a crucial issue is proper collection, labeling, storage and shipping of COVID-19 specimens to CDC laboratories for testing. Among procedures spelled out in the CDC’s Interim Guidelines is that coronavirus specimen shipments must be stored at 2-8⁰C and shipped overnight on icepack for testing within 72 hours. If a delay in shipping is expected, specimens must be stored at -70⁰C or lower. These agree with a companion guideline for post-mortem testing

Temperature Guidelines for COVID-19 Test Kits

Because there are so many sites collecting specimens there is a national shortage of reagents for the tests. Test kits are available for real-time PCR and in vitro diagnostic procedures.  One manufacturer specifies storage temperatures from -10⁰ to -30⁰C down to ≤-70⁰C depending on the components of the kits.

To meet these storage requirements you should be familiar with

  • Scientific Refrigerators
  • Scientific Freezers
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How Ultrasonic Cleaners Protect Dentists in the Corona Virus Pandemic

How Ultrasonic Cleaners Protect Dentists in the Corona Virus Pandemic

The American Dental Association releases guideline updates on how dental technicians can protect themselves during the current Corona Virus pandemic.  The ADA on March 16 encouraged dental practitioners to postpone elective procedures for the next three weeks.  It also refers dentists to conform to CDC guidelines for sterilizing and disinfecting patient care items and devices.

These guidelines refer to reusable dental instruments, and among other techniques recommend the use of ultrasonic cleaners as a pre-sterilization or disinfecting procedure to render them safely for reuse.

Ultrasonic Cleaners In CDC Recommendations for Covid-19 Infection Control

The CDC’s 2008 Infection and Sterilization Guideline notes that “The most common types of mechanical or automatic cleaners are ultrasonic cleaners…” and that “Ultrasonic cleaning removes soil by cavitation and implosion in which waves of acoustic energy are propagated in aqueous solutions to disrupt the bonds that hold particulate matter to surfaces.”

Note that ultrasonic cleaning … Read the rest