Tablet splitting is a common practice when you need to give less than a full dose. However this has significant risks as this study found out. Five volunteers were asked to mimic the practice in nursing homes using a splitting device, a scissor, and a kitchen knife. The splitting device turned out to be the most accurate way to split a tablet. Using an analytical balance the researchers measured the difference between each of the methods before and after the split. The scissor and knife produced statistically similar results while the splitting device had a statistically significant lower mean deviation from the theoretical weight after the split. There was also significantly less weight loss with the device than with the knife or scissors.
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