Posts Tagged ‘flow meter’

Pump system accuracy is crucial for equipment used to conduct high performance liquid chromatography (HPLC) analysis in the pharmaceutical and other industries subject to regulatory oversight by the FDA and similar authorities. Among functions performed by HPLC are included checks for purity, monitoring changes in pharmaceutical intermediates during chemical synthesis scale-up, stability and dissolution tests, and performing ongoing quality control procedures.Click to download PDF

A Brief on HPLC Analysis

Identifying an analyte by HPLC is based on accurate and reproducible column retention time as the analyte is pumped through an HPLC system.  Reproducible retention time is critical and depends on accurate, uniform, reproducible HPLC pump flow rates.

Note that it is important to distinguish between accuracy and precision.  These two terms may seem the same but they are not necessarily so.  For example, an HPLC system (or for that matter many other systems such as analytical scales) may … Read the rest